A carefully thought out method of harvesting and arraying tissue samples into blocks provides a simple but powerful way of reliably producing extremely large tissue microarrays using commonly ...

Here, we describe the optimization of a miniaturized cell spot microarray (CSMA) method, which facilitates utilization of the transfection microarray technique for disparate RNAi analyses. To promote ...

Advances in material science combined with nanofabrication and computational design have led to the discovery of label-free protein microarray techniques. These techniques are of enormous benefit for ...

When researchers measure the activity of thousands of genes at once, they face a paradox that has shaped computational biology for decades: far too many variables and far too few samples. A single DNA ...

MicroRNAs (miRNAs) are small, short non-coding RNAs that bind to specific messenger RNAs (mRNAs) and regulate gene expression either by degradation or by translational inhibition of the mRNA. miRNAs ...

Relationship of pro-angiogenic factor Cyr61to colorectal cancer development and prognosis. Background: Microarrays are widely used to study gene expression patterns in cancer. In colorectal cancer, it ...

Curious about how to detect and characterize tumor-derived biomarkers from liquid biopsy samples? Genomics-based methods now provide access to more molecular data than ever before, delivering cancer ...

Monitoring the behavior of gene expression over time is important and will be a common experimental design in the future. We developed a general statistical significance method for detecting temporal ...

Early Completion of Model-Assisted Designs for Dose-Finding Trials Accurate assessment of a molecular classifier that guides patient care is of paramount importance in precision oncology. Recent years ...